Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.Īging is a biological process that is characterized by time-dependent cellular and functional decline, resulting in reduced quality of life for the organism 1. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival.
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